Do Multiple Update statement

I want to update a field for many records from an Excel Spreadsheet. The number of recs is >1000 and a once off thing. I thought to generate these update statements in the spread sheet and paste multiple Update commands into Toad. Toad doesn’t seem to recognize any end of statement syntax. Is it possible to run multiple update commands in TOAD or am I going about this the worng way altogether.
Thanks!