Hi,
We have had TOAD version 25 installed, replaced 17, and since the new version has been installed F5 and the button to execute has script fails. Nothing runs, no errors or anything. F9 works fine.
tried logging but to be honest this logs mean nothing.
any ideas on what to troubleshoot?
It seems like the Windows Exploit Protection is blocking the F5 option.
If you open Windows Security and go into App & browser control, then open the "Exploit protection settings". Once there select Program settings and then choose "Add program to customize" and add TOAD.exe as an application. I overrode two items as I saw 1 in particular that excel and other applications were overriding.
The two options I overrode were Data Execution Prevention (off) and Force randomization for images (on).
This worked for me, but you may need to play with it a bit for you and remember that those options are there to protect you. 
Dan