Around the time of Toad 13/14, we enabled settings in Toad and related DLLs against exploit protection. For 99.9% of users, it went unnoticed, but for some, we got reports of F5 doing nothing because Windows Defender thought it was a virus/hack. There was actually a recent post here in the forum about it.
I wonder if that is at all related. For those who were having problems with Toad running (or running scripts), these steps helped. I don't know if this will solve anything for you but maybe it's worth a try.
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Click on the windows search and type in "Security". Click on the "Windows Security" app.
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On the right, click "App and browser control"
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On the right, click "Exploit protection settings"
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Exploit Protection Settings comes up on the "System Settings" tab. Click it over to "Program Settings"
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If "Toad.exe" is not in the list, add it. You can just add it by program name and not full path.
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Scroll down to "Randomize memory allocations (Bottom-up ASLR)". Check "Override system settings" and "Off". (Note: Checking "Don't use high entropy" works too.)