Toad's main menu and toolbar are pretty crowded. This is what I do to simplify it whenever I get a new Toad installed. I just wanted to put some ideas out there on how to make Toad look less complicated. You may not want to hide everything that I did. Do what works for you.
Edit: Oh, and I forgot - in the login window. I like to filter it to just connections made in the last 7 days. It keeps the list of connections to a manageable number.