Toad Data Point 3.2 Pro-connection manager change local storage

I am running out of c drive disk space when running queries. I searched Toad World and found a solution to change the Connection Manager local storage temp file location. I did that and it appeared to work, but now I cannot get my query to run. I press F5 and the query does not execute. I notice that the execute icon is not available on the tool bar. Thank you in advance for your assistance.

Could you provide more information about the issue please?
What queries cause the problem with the disk space?
What connections do you use to execute the queries?
What the “local storage temp file location” are you taking about? Do you mean Tools | Options | Local Storage folder setting?
What queries cannot you run now? What connection do you use to run the queries now?