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Login to oracle throws exception OCI_INVALID_HANDLE

I have installed oracle Toad 12.1 but when i connect to some databases using toad . I gets the error of "OCI_INVALID_HANDLE".

Please guide me what actually the issue is behind the scene.

I have seen this error occasionally when the ORACLE_HOME env variable is not set properly, or not set to the proper oracle client location. May want to check the env variable first, then double check that your oracle client is installed correctly.

Same was the reason behind.
Thank you