It still doesn't work properly in TOAD 14.2 Beta, please see the other topic I opened a few weeks ago:
https://forums.toadworld.com/t/change-of-keyboard-shortcuts-doesnt-work-in-toad-14/51345/24
There's still the issue that the shortcut changes (in my case F8 and F9) don't work sometimes after a TOAD restart. Although they are displayed in then "changed way" (F8 Execute, F9 SQL Recall), they behave like TOAD default.